InterPro domain: IPR036950

Penicillin-binding proteins, such as Escherichia coli PBP1b, are bifunctional transglycosylases that consist of a transmembrane helix, a transglycosylase domain and a transpeptidase domain [ 1 ]. The transglycosylase domain catalyses the polymerisation of murein glycan chains [ 2 ]. This domain is also found on its own in monofunctional peptidoglycan transglycosylases [ 3 ].

1. Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 106, 8824-9
2. The glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae catalyzes the polymerization of murein glycan chains. J. Bacteriol. 185, 4418-23
3. Monofunctional biosynthetic peptidoglycan transglycosylases. Mol. Microbiol. 19, 639-40