InterPro domain: IPR036861

A number of plant and fungal proteins that bind N-acetylglucosamine (e.g. solanaceous lectins of tomato and potato, plant endochitinases, the wound-induced proteins: hevein, win1 and win2, and the Kluyveromyces lactis killer toxin alpha subunit) contain this domain [ 1 ]. The domain may occur in one or more copies and is thought to be involved in recognition or binding of chitin subunits [ 2 , 3 ]. In chitinases, as well as in the potato wound-induced proteins, the 43-residue domain directly follows the signal sequence and is therefore at the N terminus of the mature protein; in the killer toxin alpha subunit it is located in the central section of the protein.

1. Evolution of a family of N-acetylglucosamine binding proteins containing the disulfide-rich domain of wheat germ agglutinin. J. Mol. Evol. 33, 283-94
2. Kluyveromyces lactis toxin has an essential chitinase activity. Eur. J. Biochem. 199, 483-8
3. The gene for stinging nettle lectin (Urtica dioica agglutinin) encodes both a lectin and a chitinase. J. Biol. Chem. 267, 11085-91