InterPro domain: IPR036846
General Information
- Identifier IPR036846
- Description GM2-AP, lipid-recognition domain superfamily
- Number of genes 13
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Abstract
Ganglioside GM2 activator (GM2-AP) is a is a lysosomal lipid transfer protein that is essential for the hydrolytic conversion of ganglioside GM2 to GM3 by beta-hexosaminidase A [ 1 ]. The crystal structure of apo-GM2-AP consists of a novel beta-cup fold with a spacious hydrophobic interior [ 2 , 3 ].
1. Structural analysis of lipid complexes of GM2-activator protein. J. Mol. Biol. 331, 951-64
2. Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity. Biochemistry 44, 13510-21
Species distribution
Gene table
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