InterPro domain: IPR036846

General Information

  • Identifier IPR036846
  • Description GM2-AP, lipid-recognition domain superfamily
  • Number of genes 13
  • Gene duplication stats Loading...

Abstract

Ganglioside GM2 activator (GM2-AP) is a is a lysosomal lipid transfer protein that is essential for the hydrolytic conversion of ganglioside GM2 to GM3 by beta-hexosaminidase A [ 1 ]. The crystal structure of apo-GM2-AP consists of a novel beta-cup fold with a spacious hydrophobic interior [ 2 , 3 ].


1. Structural analysis of lipid complexes of GM2-activator protein. J. Mol. Biol. 331, 951-64
2. Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity. Biochemistry 44, 13510-21

Species distribution

Gene table