InterPro domain: IPR036844

This entry represents a domain superfamily found in the pretoxin HINT domain protein and the C-terminal of protein hedgehog.

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autoprocessing domain shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the Hedgehog/Intein (Hint) domain [ 1 ].

1. Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. Cell 92, 1-4