InterPro domain: IPR036822

General Information

  • Identifier IPR036822
  • Description Copper homeostasis (CutC) domain superfamily
  • Number of genes 4
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005507   GO:0055070  

Abstract

CutC is a protein involved in copper homeostasis [ 1 ]. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity.

The CutC monomer structure adopts a common TIM beta/alpha barrel with 8 beta strands surrounded by 8 alpha helices [ 2 ].


1. Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli. J. Bacteriol. 177, 4207-15
2. Crystal structure of the copper homeostasis protein (CutCm) from Shigella flexneri at 1.7 A resolution: the first structure of a new sequence family of TIM barrels. Proteins 58, 764-8

Species distribution

Gene table