InterPro domain: IPR036794
General Information
- Identifier IPR036794
- Description ATP synthase delta/epsilon subunit, C-terminal domain superfamily
- Number of genes 4
- Gene duplication stats Loading...
Abstract
This entry represents the C-terminal long alpha-helix domain superfamily of ATPase subunits delta (in mitochondrial ATPase) or epsilon (in bacteria or chloroplast ATPase) [ 1 ].
The interaction site of subunit C of the F0 complex with the delta or epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit) [ 2 ]. In bacterial species, the delta subunit is the equivalent of the Oligomycin sensitive subunit (OSCP, IPR000711 ) in metazoans. The C-terminal domain of the epsilon subunit appears to act as an inhibitor of ATPase activity [ 3 ].
1. Crystal structure of the epsilon subunit of the proton-translocating ATP synthase from Escherichia coli. Structure 5, 1219-30
2. ATP synthases: insights into their motor functions from sequence and structural analyses. J. Bioenerg. Biomembr. 35, 95-120
3. Inhibition of ATP hydrolysis by thermoalkaliphilic F1Fo-ATP synthase is controlled by the C terminus of the epsilon subunit. J. Bacteriol. 188, 3796-804