InterPro domain: IPR036767

The apaG domain is a ~125 amino acids domain present in bacterial apaGproteins and in eukaryotic F-box proteins. The domain is named after thebacterial apaG protein, of which it forms the core. The domain also occurs inthe C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD isinvolved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures fromdifferent apaG proteins show a fold of several beta-sheets.The apaG domain may be involved in protein-protein interactions which could beimplicated in substrate-specificity [ 1 , 2 , 3 , 4 ].

1. Magnesium transport in Salmonella typhimurium: the influence of new mutations conferring Co2+ resistance on the CorA Mg2+ transport system. Mol. Microbiol. 5, 2753-62
2. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Genomics 67, 40-7
3. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. J. Biol. Chem. 278, 10041-7
4. 1H, 15N and 13C resonance assignments of the ApaG protein of the phytopathogen Xanthomonas axonopodis pv. citri. J. Biomol. NMR 29, 423-4