InterPro domain: IPR036748
General Information
- Identifier IPR036748
- Description MTH938-like superfamily
- Number of genes 152
- Gene duplication stats Loading...
Abstract
MTH938 is a hypothetical protein encoded by Methanobacterium thermoautotrophicum. The crystal structure of MTH938 consists of three beta-sheets and three alpha-helices [ 1 ].
This superfamily also includes NDUFAF3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) [ 2 ], and Mth938 domain-containing protein [ 3 ].
1. X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold. Proteins 45, 486-8
2. Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. Am. J. Hum. Genet. 84, 718-27
3. LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells. J. Nutr. 142, 448-55