InterPro domain: IPR036738
General Information
- Identifier IPR036738
- Description FKBP12-rapamycin binding domain superfamily
- Number of genes 142
- Gene duplication stats Loading...
- Associated GO terms GO:0044877
Abstract
The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the Tor proteins.
This superfamily represents the FRB domain [ 1 , 2 ]. Proteins containing this domain include Tor proteins which are serine/threonine kinases conserved from fungi to humans. While higher eukaryotes such as humans possess a single Tor protein, yeasts contain two (Tor1 and Tor2) [ 3 ].
1. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 273, 239-42
2. Ubiquitin regulates TORC1 in yeast Saccharomyces cerevisiae. Mol. Microbiol. 58, 977-88
3. Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Mol. Cell