InterPro domain: IPR036706

Vitelline membrane outer layer protein I (VMO-I) is one of the proteins found in the outer layer of the vitelline membrane of eggs. VMO-I, lysozyme, and VMO-II are bound tightly to ovomucin fibrils of the egg yolk membrane. The structure of VMO-I [ 1 ] consists of three beta-sheets forming Greek key motifs, which are related by an internal pseudo three-fold symmetry. It is a member of the beta-prism-fold family and the structure of VOM-I has strong similarity to the structure of the delta-endotoxin, as well as a carbohydrate-binding site in the top region of the common fold [ 2 ]. VMO-I has been shown to synthesize N-acetylchito-oligosaccharides from N-acetylglucosamine.

1. Crystal structure of vitelline membrane outer layer protein I (VMO-I): a folding motif with homologous Greek key structures related by an internal three-fold symmetry. EMBO J. 13, 1003-10
2. The beta-prism: a new folding motif. Trends Biochem. Sci. 21, 3-6