InterPro domain: IPR036703

The MOB kinase activator superfamily includes MOB1, an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [ 1 ]. This superfamily also includes the MOB-like protein phocein, an intracellular protein that interacts with striatin and may play a role in membrane trafficking [ 2 ]. Structurally, domains in this superfamily have a bromodomain-like fold, which consists of four helices arranged as a bundle with a minor mirror variant of up-and-down topology; they also contain a zinc-binding site.

1. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol. Biol. Cell 9, 29-46
2. Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. J. Biol. Chem. 277, 18961-6