InterPro domain: IPR036651

Glutamine synthetase ( 6.3.1.2 ) (GS) [ 1 ] plays an essential role in the metabolism of nitrogen by catalysing the condensation of glutamate and ammonia to form glutamine. This entry represents the glutamine synthetase N-terminal domain, which adopts a beta-grasp fold [ 2 ] and contributes to the substrate binding pocket of the enzyme [ 3 , 4 ].

1. Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO. Cold Spring Harb. Symp. Quant. Biol. 52, 483-90
2. Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold. Biol. Direct 2, 18
3. Novel subunit-subunit interactions in the structure of glutamine synthetase. Nature 323, 304-9
4. The structures of cytosolic and plastid-located glutamine synthetases from Medicago truncatula reveal a common and dynamic architecture. Acta Crystallogr D Biol Crystallogr 70, 981-93