InterPro domain: IPR036642

General Information

  • Identifier IPR036642
  • Description Cytochrome b-c1 complex subunit 8 superfamily
  • Number of genes 158
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005750   GO:0006122  

Abstract

The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multi-enzyme complex [ 1 ], which recognises a mitochondrial targeting presequence. The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske protein), 2 core proteins and 6 low molecular weight proteins. This entry represents the 9.5kDa subunit of the complex, known as subunit 8 or protein QP-C [ 2 ]. This subunit together with cytochrome B binds to ubiquinone.


1. Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Science 281, 64-71
2. A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis. Hum. Genet. 113, 118-22

Species distribution

Gene table