InterPro domain: IPR036627
General Information
- Identifier IPR036627
- Description CobW-like, C-terminal domain superfamily
- Number of genes 362
- Gene duplication stats Loading...
Abstract
CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis [ 1 , 2 ]. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids.
This entry represents the C-terminal domain found in CobW, as well as in P47K ( P31521 ), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression [ 3 ].
1. Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes. J. Biol. Chem. 278, 41148-59
2. Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases. Biochemistry 52, 1788-1801
3. Nitrile hydratase gene from Rhodococcus sp. N-774 requirement for its downstream region for efficient expression. Biosci. Biotechnol. Biochem. 58, 1859-65