InterPro domain: IPR036616
General Information
- Identifier IPR036616
- Description Poly(ADP-ribose) polymerase, regulatory domain superfamily
- Number of genes 355
- Gene duplication stats Loading...
- Associated GO terms GO:0006471 GO:0003950
Abstract
Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The regulatory domain of the polymerase is almost always associated with the C-terminal catalytic domain (see IPR012317 ).
This domain consists of a duplication of two helix-loop-helix structural repeats [ 1 ].
1. Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling. Biochemistry 37, 3893-900
Species distribution
Gene table
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