InterPro domain: IPR036607
General Information
- Identifier IPR036607
- Description Glucosidase 2 subunit beta-like
- Number of genes 146
- Gene duplication stats Loading...
Abstract
The sequences found in this entry are similar to a region found in the beta-subunit of glucosidase II ( P14314 ), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [ 1 ]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [ 2 ]. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit [ 2 ].
1. The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Glycobiology 10, 815-27
2. Genetic analysis of glucosidase II beta-subunit in trimming of high-mannose-type glycans. Glycobiology 19, 834-40