InterPro domain: IPR036517

The FF domain may be involved in protein-protein interaction [ 1 ]. It often occurs as multiple copies and often accompanies WW domains IPR001202 . PRP40 from yeast encodes a novel, essential splicing component that associates with the yeast U1 small nuclear ribonucleoprotein particle [ 2 ].

This entry represents the FF domain superfamily.

The structure of the FF domain is composed of three alpha helices arranged in an orthogonal bundle with a 3(10) helix in the loop between the second and third alpha helices [ 3 ].

1. The FF domain: a novel motif that often accompanies WW domains. Trends Biochem. Sci. 24, 264-5
2. Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle. Mol. Cell. Biol. 16, 960-7
3. The structure of an FF domain from human HYPA/FBP11. J. Mol. Biol. 323, 411-6