InterPro domain: IPR036497

Glycolipid transfer protein (GLTP) is a cytosolic protein that catalyses the intermembrane transfer of glycolipids such as glycosphingolipids, glyceroglycolipids, and possibly glucosylceramides, but not of phospholipids. The GLTP protein consists of a single domain with a multi-helical structure consisting of two layers of orthogonally packed helices [ 1 , 2 ].

The GLTP domain is also found in trans-Golgi network proteins involved in Golgi-to-cell-surface membrane traffic [ 3 ].

1. Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. Biochemistry 43, 13805-15
2. Structural evidence for adaptive ligand binding of glycolipid transfer protein. J. Mol. Biol. 355, 224-36
3. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat. Cell Biol. 6, 393-404