InterPro domain: IPR036477
General Information
- Identifier IPR036477
- Description Formyl transferase, N-terminal domain superfamily
- Number of genes 450
- Gene duplication stats Loading...
- Associated GO terms GO:0009058 GO:0016742
Abstract
A number of formyl transferases belong to this group. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl minoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-ormylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. Formyltetrahydrofolate dehydrogenase produces formate from formyl-tetrahydrofolate. This is the N-terminal domain of these enzymes and is found upstream of the C-terminal domain ( IPR005793 ).
The trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase catalyses the second, third and fifth steps in de novo purine biosynthesis. The glycinamide ribonucleotide transformylase belongs to this group.
The formyl transferase N-terminal domain structure has a three layers (alpha/beta/alpha) fold, with a mixed beta-sheet of seven strands where strand 6 is antiparallel to the rest.