InterPro domain: IPR036452

This entry represents the structural domain superfamily of ribonucleoside hydrolase. Nucleoside hydrolases are crucial for salvaging nucleic acid components in purine auxotrophic protozoan parasites, but are also present in higher eukaryotes and prokaryotes, where they could have a role in the metabolism of tRNA nucleosides [ 1 ]. These enzymes are composed of three layers (alpha/beta/alpha), consisting of a mixed eight-stranded beta sheet surrounded by six alpha helices [ 2 ].

1. Crystal structure to 1.7 a of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy. Structure 12, 739-49
2. Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata. Biochemistry 35, 5971-81