InterPro domain: IPR036445

General Information

  • Identifier IPR036445
  • Description GPCR family 2, extracellular hormone receptor domain superfamily
  • Number of genes 3
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004930   GO:0016020  

Abstract

This domain superfamily is found in the extracellular part of some of the secretin-like (family 2) GPCRs including the corticotropin releasing factor receptor 1; calcitonin receptor; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor. The N-terminal extracellular domain is the major ligand recognition domain [ 1 ]. This domain structure has a disulfide-rich all-beta fold and contains a beta sandwich of 5 strands.


1. NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 101, 12836-41

Species distribution

Gene table