InterPro domain: IPR036428

General Information

  • Identifier IPR036428
  • Description Pterin 4 alpha carbinolamine dehydratase superfamily
  • Number of genes 247
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006729   GO:0008124  

Abstract

Pterin 4 alpha carbinolamine dehydratase is also known as DCoH. DCoH is the dimerisation cofactor of hepatocyte nuclear factor 1 (HNF-1) that functions as both a transcriptional coactivator and a pterin dehydratase [ 1 ]. X-ray crystallographic studies have shown that the ligand binds at four sites per tetrameric enzyme, with little apparent conformational change in the protein.

DCoH has a beta(2)-alpha-beta(2)-alpha fold arranged in two alpha/beta layers.


1. High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue. Protein Sci. 5, 1963-72

Species distribution

Gene table