InterPro domain: IPR036422
General Information
- Identifier IPR036422
- Description RuBisCO large subunit, N-terminal domain superfamily
- Number of genes 358
- Gene duplication stats Loading...
- Associated GO terms GO:0015977 GO:0016984
Abstract
Ribulose bisphosphate carboxylase (RuBisCO) [ 1 , 2 ] catalyses the initial step in Calvin's reductive pentose phosphate cycle in plants as well as purple and green bacteria. It catalyzes the primary CO2 fixation step. Rubisco is activated by carbamylation of an active site lysine, stabilized by a divalent cation, which then catalyzes the proton abstraction from the substrate ribulose 1,5 bisphosphate (RuBP) and leads to the formation of two molecules of 3-phosphoglycerate [ 3 , 4 ].
1. Ribulose-1,5-bisphosphate carboxylase-oxygenase. Annu. Rev. Biochem. 52, 507-35
2. Rubisco: structure, regulatory interactions, and possibilities for a better enzyme. J. Biol. Chem. 53, 449-75
3. Examination of the intersubunit interaction between glutamate-48 and lysine-168 of ribulose-bisphosphate carboxylase/oxygenase by site-directed mutagenesis. J. Mol. Biol. 265, 6501-5
4. The structure of the complex between rubisco and its natural substrate ribulose 1,5-bisphosphate. null 265, 432-44