InterPro domain: IPR036409

This entry represents the alpha/beta/alpha domain found in class II aldolases and in adducin (usually at the N terminus of adducin). Proteins containing this domain include: rhamnulose-1-phosphate aldolase ( 4.1.2.19 ), L-fuculose phosphate aldolase ( 4.1.2.17 ) [ 1 , 2 ] that is involved in the third step in fucose metabolism, L-ribulose- 5-phosphate 4-epimerase ( 5.1.3.4 ) involved in the third step of L-arabinose catabolism, a probable sugar isomerase SgbE and the metazoan adducins, which have not been ascribed any enzymatic function but which play a role in cell membrane cytoskeleton organisation [ 3 ].

This entry also includes the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine.

1. The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli. J. Mol. Biol. 231, 549-53
2. Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure. J. Mol. Biol. 259, 458-66
3. Primary structure and domain organization of human alpha and beta adducin. J. Cell Biol. 115, 665-75