InterPro domain: IPR036406
General Information
- Identifier IPR036406
- Description Oxygen-dependent coproporphyrinogen III oxidase superfamily
- Number of genes 162
- Gene duplication stats Loading...
- Associated GO terms GO:0006779 GO:0004109
Abstract
Coprogen oxidase (i.e. coproporphyrin III oxidase or coproporphyrinogenase) catalyses the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the haem and chlorophyll biosynthetic pathways [ 1 , 2 ]. The protein is a homodimer containing two internally bound iron atoms per molecule of native protein [ 3 ]. The enzyme is active in the presence of molecular oxygen that acts as an electron acceptor. The enzyme is widely distributed having been found in a variety of eukaryotic and prokaryotic sources.
The coprogen oxidase has an alpha-beta(6)-alpha(2)-beta-alpha(n) structure. It is composed of three layers (alpha/beta/alpha) with antiparallel sheets.
1. Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation. J. Biol. Chem. 268, 21359-63
2. A soybean coproporphyrinogen oxidase gene is highly expressed in root nodules. Plant Mol. Biol. 23, 35-43
3. Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. Eur. J. Biochem. 156, 579-87