InterPro domain: IPR036402
General Information
- Identifier IPR036402
- Description Elongation factor Ts, dimerisation domain superfamily
- Number of genes 275
- Gene duplication stats Loading...
Abstract
Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta) [ 1 ].
This superfamily describes a beta(2)-alpha(n)-beta two layers (alpha-beta) fold domain of EF-Tu (EF1A). In E. coli and mitochondrial Ts there are two subdomains of this fold [ 2 , 3 ].
1. Structural studies of eukaryotic elongation factors. Cold Spring Harb. Symp. Quant. Biol. 66, 425-37
2. The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature 379, 511-8
3. Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex. J. Biol. Chem. 280, 5071-81