InterPro domain: IPR036394
General Information
- Identifier IPR036394
- Description Ribosomal protein L22/L17 superfamily
- Number of genes 683
- Gene duplication stats Loading...
- Associated GO terms GO:0003735 GO:0005840 GO:0006412
Abstract
Ribosomal protein L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome [ 1 , 2 ].
1. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science 289, 905-20
2. L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin. J. Mol. Biol. 322, 635-44