InterPro domain: IPR036348

Partner of Y14 and mago (PYM, also known as WIBG) is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation [ 1 , 2 ].

The N-terminal domain of PYM adopts a small globular all-beta-domain structure, with a three-stranded beta-sheet and a contiguous beta-hairpin. It binds to both Mago and Y14 [ 3 ].

1. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Nat. Struct. Mol. Biol. 14, 1173-9
2. Disassembly of exon junction complexes by PYM. Cell 137, 536-48
3. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep. 5, 304-10