InterPro domain: IPR036277

General Information

  • Identifier IPR036277
  • Description SMCs flexible hinge superfamily

Abstract

This entry represents the hinge region superfamily of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that its precise structure is an essential determinant of the specificity of the DNA-protein interaction [ 1 ].

The structure of this hinge region consists of two different alpha+beta subdomains and forms subdomain-swapped dimers.


1. Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. EMBO J. 21, 5733-44

Species distribution

Gene table