InterPro domain: IPR036191

General Information

  • Identifier IPR036191
  • Description RRF superfamily
  • Number of genes 260
  • Gene duplication stats Loading...

Abstract

The ribosome recycling factor or ribosome release factor (RRF) dissociates ribosomes from mRNA after termination of translation, and is essential for bacterial growth [ 1 ]. Thus ribosomes are 'recycled' and ready for another round of protein synthesis.

Structurally, it is an L-shaped molecule [ 2 , 3 ].


1. Ribosome recycling factor (ribosome releasing factor) is essential for bacterial growth. Proc. Natl. Acad. Sci. U.S.A. 91, 4249-53
2. Crystal structure of the ribosome recycling factor from Escherichia coli. EMBO J. 19, 2362-70
3. X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit. EMBO J. 24, 251-60

Species distribution

Gene table