InterPro domain: IPR036189
General Information
- Identifier IPR036189
- Description mRNA decapping protein 2, Box A domain superfamily
- Number of genes 171
- Gene duplication stats Loading...
- Associated GO terms GO:0003723 GO:0030145 GO:0016787
Abstract
This superfamily represents the box A specific to mRNA decapping protein 2 P53550 , Dcp2, the catalytic subunit of the mRNA-decapping enzyme [ 1 ], which is found at the N-terminal of the NUDIX hydrolase domain IPR000086 . Removal of the cap structure is mediated by the Dcp1-Dcp2 complex [ 2 ].
The Box A domain contains a four helices fold and an orthogonal array of two alpha hairpins topology.
1. The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc. Natl. Acad. Sci. U.S.A. 99, 12663-8
2. Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat. Struct. Mol. Biol. 13, 63-70
Species distribution
Gene table
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