InterPro domain: IPR036189

This superfamily represents the box A specific to mRNA decapping protein 2 P53550 , Dcp2, the catalytic subunit of the mRNA-decapping enzyme [ 1 ], which is found at the N-terminal of the NUDIX hydrolase domain IPR000086 . Removal of the cap structure is mediated by the Dcp1-Dcp2 complex [ 2 ].

The Box A domain contains a four helices fold and an orthogonal array of two alpha hairpins topology.

1. The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc. Natl. Acad. Sci. U.S.A. 99, 12663-8
2. Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat. Struct. Mol. Biol. 13, 63-70