InterPro domain: IPR036148
General Information
- Identifier IPR036148
- Description MmgE/PrpD superfamily
- Number of genes 5
- Gene duplication stats Loading...
- Associated GO terms GO:0016829
Abstract
MmgE/PrpD superfamily members include 2-methylcitrate dehydratase (PrpD; 4.2.1.79 ) and citrate/2-methylcitrate dehydratase MmgE. PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle [ 1 ]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha beta domain [ 2 ]. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family. CAD is essential for itaconic acid production in Aspergillus terreus [ 3 ].
1. AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. Microbiology (Reading, Engl.) 148, 133-46
2. Three-dimensional structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family. J. Mol. Biol. 362, 555-66
3. Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus. Appl. Microbiol. Biotechnol. 80, 223-9