InterPro domain: IPR036127

CcmE is the product of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in many prokaryotes [ 1 , 2 ] and plant mitochondria [ 3 ]. In E. coli, expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor [ 4 ].

The CcmE structure presents a close or partly open barrel fold and a greek-key topology.

1. Prototype of a heme chaperone essential for cytochrome c maturation. Science 281, 1197-200
2. Solution NMR structure, backbone dynamics, and heme-binding properties of a novel cytochrome c maturation protein CcmE from Desulfovibrio vulgaris. Biochemistry 51, 3705-7
3. CCME, a nuclear-encoded heme-binding protein involved in cytochrome c maturation in plant mitochondria. J. Biol. Chem. 276, 5491-7
4. Escherichia coli genes required for cytochrome c maturation. J. Bacteriol. 177, 4321-6