InterPro domain: IPR036063

The Smr domain is an around 90-residue domain found in:

• The C-terminal region of the mutS2 proteins from bacteria and plants.
• The small mutS related (smr) proteins from bacteria and eukaryotes.

These proteins could be involved in mismatch repair (MMR) or/and chromosomecrossing-over and segregation. It has been proposed that the Smr domain actsas a nicking endonuclease [ 1 , 2 ].

This entry represents the Smr domain superfamily.

The structure of the Smr domain has a beta-alpha-beta-alpha-beta(2) fold. It is divided into two layers and the strand 4 is antiparallel to the rest.

1. Smr: a bacterial and eukaryotic homologue of the C-terminal region of the MutS2 family. Trends Biochem. Sci. 24, 298-300
2. Dual recognition-incision enzymes might be involved in mismatch repair and meiosis. Trends Biochem. Sci. 25, 414-8