InterPro domain: IPR035985

General Information

  • Identifier IPR035985
  • Description Ubiquitin-activating enzyme
  • Number of genes 1527
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008641  

Abstract

Ubiquitin-activating enzyme (E1 enzyme) [ 1 , 2 ] activates ubiquitin by firstadenylating with ATP its C-terminal glycine residue and thereafter linkingthis residue to the side chain of a cysteine residue in E1, yielding anubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety istransferred to a cysteine residue on one of the many forms of ubiquitin-conjugating enzymes (E2).


1. Genetic analysis of the ubiquitin system. Biochim. Biophys. Acta 1089, 127-39
2. The ubiquitin pathway for protein degradation. Trends Biochem. Sci. 16, 265-8

Species distribution

Gene table