InterPro domain: IPR035810

Phosphatidylethanolamine-binding proteins (PEBPs) are present in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1), which function as a promoter and a repressor of the floral transitions respectively [ 1 , 2 , 3 ], as well as the mammalian Raf kinase inhibitory protein (RKIP), also known as phosphatidylethanolamine-binding protein 1 (PEBP-1), which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades [ 4 , 5 ]. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).

1. Export of FT protein from phloem companion cells is sufficient for floral induction in Arabidopsis. Curr. Biol. 17, 1055-60
2. Arabidopsis TERMINAL FLOWER1 is involved in the regulation of flowering time and inflorescence development through transcriptional repression. Plant Cell 23, 3172-84
3. A divergent external loop confers antagonistic activity on floral regulators FT and TFL1. EMBO J. 25, 605-14
4. Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res. 18, 452-7
5. Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J. Biol. Chem. 287, 23407-17