InterPro domain: IPR035808

Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA, as well as the 5S rRNA, and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L7 members have an N-terminal extension not found in the archeal L7 orthologues. L7 is closely related to the ribosomal L30 protein found in eukaryotes and prokaryotes [ 1 , 2 ].

This domain is also found in ribosome biogenesis protein RLP7, which is a homologue of L7 [ 3 ].

1. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science 289, 905-20
2. Crystal structure of the eukaryotic ribosome. Science 330, 1203-9
3. Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles. Nucleic Acids Res. 41, 9461-70