InterPro domain: IPR035782

This SPRY domain is found in Ran binding protein M (RanBPM, also known as RanBP9) and RanBP10. RanBPM and RanBP10 are non-canonical members of the Ran binding protein family that lack the Ran binding domain and do not associate with Ran GTPase in vivo. RanBPM is a scaffolding protein important for a variety of cellular processes [ 1 , 2 ]. RanBP10 has been shown to function as a cytosolic guanine exchange factor and microtubule regulator [ 3 , 4 ]. Both of these proteins contain a SPRY domain, which has been implicated in mediating protein-protein interactions with a variety of targets, including the DEAD-box containing ATP-dependent RNA helicase (DDX-4) [ 5 , 6 , 7 ].

1. Diverse roles of the scaffolding protein RanBPM. Drug Discov. Today 120, 3594-602
2. RanBPM, a scaffolding protein in the immune and nervous systems. J Neuroimmune Pharmacol 2, 290-5
3. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J. Biol. Chem.
4. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Blood 96, 102-11
5. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Genomics 67, 1-7
6. Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Mol. Reprod. Dev. 428, 4330-4344
7. Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development. J. Mol. Biol. 283, 14109-19