InterPro domain: IPR035778

This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of heterogeneous nuclear ribonucleoprotein U (hnRNP U) and hnRNP U-like proteins 1 and 2.

hnRNP U contains three conserved domains: a SAF-Box that binds to AT-rich chromosomal region known as a scaffold- or matrix-attachment region (S/MAR), SPRY (Spla and Ryanodine receptor) domain of unknown function, and RGG (arginine-glycine-glycine) RNA-binding domain. hnRNP U is involved in transcription [ 1 ], alternative splicing [ 2 ] and inactivation one of the two female X chromosomes [ 3 ]. hnRNP U-like proteins 1 and 2 play key roles in cellular responses to double-strand breaks (DSBs) [ 4 , 5 ].

1. H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex. Biochim. Biophys. Acta 1830, 4899-906
2. hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L. J. Biol. Chem. 288, 8575-84
3. The matrix protein hnRNP U is required for chromosomal localization of Xist RNA. Dev. Cell 19, 469-76
4. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol. Cell 45, 505-16
5. The role of hnRPUL1 involved in DNA damage response is related to PARP1. PLoS ONE 8, e60208