InterPro domain: IPR035655

General Information

  • Identifier IPR035655
  • Description 116kDa U5 small nuclear ribonucleoprotein component, C-terminal
  • Number of genes 134
  • Gene duplication stats Loading...

Abstract

This domain is found in the C-terminal portion of the spliceosomal human 116kDa U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116kDa), and its yeast counterpart Snu114p. This domain is homologous to the C-terminal domain of the eukaryotic translational elongation factor EF-2 [ 1 ]. Yeast Snu114p is a GTPase component of U5 snRNP essential for pre-mRNA splicing [ 2 , 3 , 4 ].


1. An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J. 16, 4092-106
2. Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170, 1063-80
3. Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing. RNA 278, 28324-34
4. Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. null 12, 862-71

Species distribution

Gene table