InterPro domain: IPR035538

This is a cyclophilin-type peptidylprolyl cis-trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). It is found in a number of eukaryotic cyclophilins having the RRM domain, including the nuclear proteins: human cyclophilin-like protein PPIL4 [ 1 ], Arabidopsis thaliana AtCYP59 [ 2 ], Caenorhabditis elegans sig-7 [ 3 ] and Paramecium tetrurelia Kin241. The Kin241 protein has been shown to have a role in cell morphogenesis [ 4 ].

1. Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain. Cytogenet. Cell Genet. 95, 43-7
2. AtCyp59 is a multidomain cyclophilin from Arabidopsis thaliana that interacts with SR proteins and the C-terminal domain of the RNA polymerase II. RNA 12, 631-43
3. A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. PLoS Genet. 12, e1006227
4. KIN241: a gene involved in cell morphogenesis in Paramecium tetraurelia reveals a novel protein family of cyclophilin-RNA interacting proteins (CRIPs) conserved from fission yeast to man. Mol. Microbiol. 42, 257-67