InterPro domain: IPR035535
General Information
- Identifier IPR035535
- Description Fungal myosin-I, SH3 domain
- Number of genes 1
- Gene duplication stats Loading...
Abstract
Type I myosins (myosin-I) are actin-dependent motors in endocytic actin structures and actin patches. They play roles in membrane traffic in endocytic and secretory pathways, cell motility, and mechanosensing [ 1 ].
Saccharomyces cerevisiae has two myosins-I, Myo3 and Myo5, which are involved in endocytosis and the polarization of the actin cytoskeleton [ 2 ]. Myosin-I contains an N-terminal actin-activated ATPase, a phospholipid-binding TH1 (tail homology 1) domain, and a C-terminal extension which includes an F-actin-binding TH2 domain, an SH3 domain, and an acidic peptide that participates in activating the Arp2/3complex. The SH3 domain of myosin-I is required for myosin-I-induced actin polymerization [ 3 ].
1. Myosin I: from yeast to human. Cell. Mol. Life Sci. 65, 2128-37
2. Function and regulation of Saccharomyces cerevisiae myosins-I in endocytic budding. Biochem. Soc. Trans. 39, 1185-90
3. An intact SH3 domain is required for myosin I-induced actin polymerization. EMBO J. 19, 4281-91