InterPro domain: IPR035463
General Information
- Identifier IPR035463
- Description Peroxin 13
- Number of genes 180
- Gene duplication stats Loading...
- Associated GO terms GO:0005777 GO:0016560 GO:0016021
Abstract
Peroxin-13 (Pex13), located in the peroxisomal membrane, is a component of the peroxisomal translocation machinery with peroxin-14 and peroxin-17. Both termini of peroxin-13 are oriented to the cytosol. It is required for peroxisomal association of peroxin-14 [ 1 ]. Both human and budding yeast Pex13 bind to the PTS1 signal recognition factor Pex5. However, they bind to Pex5 through different binding sites [ 2 ]. In budding yeasts, Pex13 is also involved in the PTS2 signal recognition through its interaction with Pex7 [ 3 ].
1. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Dev. Biol. 223, 371-82
2. Pex13p: docking or cargo handling protein? Biochim. Biophys. Acta 1763, 1585-91
3. Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import. Mol. Cell. Biol. 22, 6056-69