InterPro domain: IPR035435
General Information
- Identifier IPR035435
- Description Diphthamide synthesis DHP1/DPH2, eukaryotes and archaea
- Number of genes 62
- Gene duplication stats Loading...
- Associated GO terms GO:0017183
Abstract
This entry includes diphthamide synthesis DPH1 from eukaryotes and archaea and DPH2 from archaea.
Archaeal and eukaryotic translation elongation factor 2 (EF-2) contain a unique posttranslationally modified histidine residue called diphthamide, which become the target for ADP-ribosylation by diphtheria toxin [ 1 ]. DPH1 catalyzes the first step of diphthamide biosynthesis and is required for the modification of EF-2 [ 2 ]. The human DPH1 is also known as OVCA1 (for ovarian cancer gene 1), a tumour suppressor gene that plays a crucial role in the regulation of cell proliferation, embryonic development, and tumorigenesis [ 2 ].
1. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Mol. Cell. Biol. 24, 9487-97
2. Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev. 18, 320-32