InterPro domain: IPR035426

This entry includes Gem2 (also known as SIP1) from animals, Brr1 from budding yeasts and yip11/yip12 from fission yeasts. Gem2 is part of the survival of motor neurons (SMN) complex that is involved in UsnRNP assembly in the cytoplasm and mediates nuclear import of the assembled UsnRNP [ 1 ].

Brr1 is a nuclear protein involved in mRNA splicing and required for snRNA accumulation and snRNP biogenesis [ 2 , 3 , 4 ].

1. Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 105, 10045-50
2. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J. 15, 4368-79
3. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143, 67-80
4. Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170, 1063-80