InterPro domain: IPR035256

This entry represents regulatory subunit 6B (gene name PSMC4 or Rpt3) of the 26S proteasome, which is a component of the 19S proteasome cap [ 1 ]. PSMC4 is one of the ATPases that form a heterohexameric ring for unfolding ubiquitinated proteins targeted for degradation by the proteasome, and was initially identified as Tat-binding protein 7 [ 2 ].

1. Structure of the human 26S proteasome at a resolution of 3.9 A. Proc. Natl. Acad. Sci. U.S.A. 113, 7816-21
2. Tat-binding protein 7 is a subunit of the 26S protease. Biol. Chem. Hoppe-Seyler 375, 237-40