InterPro domain: IPR035216

This entry represents subunit beta 7 of the constitutive proteasome (MEROPS identifier T01.011). This subunit, when processed, is an endopeptidase with threonine as an N-terminal nucleophile, and a preference for cleavage of lysyl and arginyl bonds in proteins and is therefore described as "trypsin-like" [ 1 ]. This subunit is known as PUP1 or beta 2 in Saccharomyces cerevisiae [ 2 , 3 ].

1. Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants. J. Biol. Chem. 273, 25637-46
2. Nucleotide sequence of PUP1 encoding a putative proteasome subunit in Saccharomyces cerevisiae. Nucleic Acids Res. 19, 5075
3. Structure of 20S proteasome from yeast at 2.4 A resolution. Nature 386, 463-71