InterPro domain: IPR035200
General Information
- Identifier IPR035200
- Description Cell division control protein 24, OB domain 2
- Number of genes 105
- Gene duplication stats Loading...
Abstract
This entry represents the second OB-fold domain found in cell division control protein 24 (Cdc24).
The OB-fold domains are nucleic acid binding domains. Cdc24 plays an essential role in the progression of normal DNA replication and is required to maintain genomic integrity [ 1 ]. Cdc24 has been reported to interact with replication factor C (RFC) as well as proliferating cell nuclear antigen (PCNA), and has been suggested to act as a target for the regulation of damage repair DNA synthesis [ 2 ].
1. Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity. Genetics 149, 1221-33
2. Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion. Mol. Cell. Biol. 19, 1038-48