InterPro domain: IPR035102

This entry includes phosphomevalonate kinases from bacteria, fungi, plants and archaea. The eukaryote enzyme is phosphomevalonate kinase Erg8 [ 1 ]. The phosphomevalonate kinase from Sulfolobus solfataricus catalyses the phosphorylation of (R)-mevalonate 5-phosphate to (R)-mevalonate 5-diphosphate and is important in the pathway for the biosynthesis of archaeal membrane lipids [ 2 ].

1. Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Mol. Cell. Biol. 11, 620-31
2. Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus. J. Biochem. 153, 415-20