InterPro domain: IPR035097

This superfamily represents a domain found in a group of metallopeptidases that belong to MEROPS peptidase family M29 (aminopeptidase T family, clan M-), and that includes AmpS and AmpT.

Staphylococcus aureus aminopeptidase S (AmpS) has been named for its predicted, but experimentally untested, aminopeptidase activity. The enzyme is homologous to biochemically characterized aminopeptidases. It is a dimeric protein with a very unusual, elongated shape and a large internal cavity [ 1 ]. Aminopeptidase T (AmpT) from Thermus thermophilus is an homologue of AmpS. AmpT, like AmpS, can be divided into an N-terminal domain and a C-terminal domain, with a flexible hinge between them [ 2 ]. This entry represent the N-terminal domain.

1. Staphylococcus aureus aminopeptidase S is a founding member of a new peptidase clan. J. Biol. Chem. 280, 27792-9
2. Substrate access to the active sites in aminopeptidase T, a representative of a new metallopeptidase clan. J. Mol. Biol. 354, 403-12